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Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'

Newly-Discovered Gene Variant Could Help Prevent or Treat Alzheimer's Disease

⏲ 1:31 👁 12.6M

Entre Ciel Et Terre

Sam Cooke - A change is gonna come - 1963

⏲ 3 minutes 11 seconds 👁 4.9M

Drummer Ami

Dokken - In my dreams drum cover by Ami Kim (192)

⏲ 4 minutes 48 seconds 👁 28.5K

Launch of Glen Rosa at Ferguson Marine<br/><br/>Glen Rosa launch: What future for Ferguson Marine as hugely-delayed ferry leaves slipway?<br/><br/>It had taken shape at Ferguson Marine over more than eight years, but then, in a matter of seconds on Tuesday, was gone – leaving behind questions about the shipyard’s future (and recent turbulent past) as big as the huge slipway it had just vacated.<br/><br/>Glen Rosa’s belated launch could turn out to be the turning point for the embattled Port Glasgow yard. But we don’t know yet whether it’s towards the brighter future wellbeing economy Mairi McAllan talked up as the ship was sent on its way, or whether the yard’s hopes have effectively sailed away with the vessel.<br/><br/>Ms McAllan, surrounded by female apprentices as she spoke, pointed to them being the future of Scottish shipbuilding, which she said meant it was “in safe hands”.<br/><br/>The Cabinet secretary said later that her officials had just taken receipt of a bid for new investment from the yard to make it more competitive – which could be vital if Ferguson Marine is to secure a crucial contract to build seven smaller CalMac ferries similar to those it successfully completed in the not-so-distant past.<br/><br/>I also understand it will have to bid for the work rather than receive a direct award, to comply with international competition rules. However, Ms McAllan made no reference to Glen Rosa – and sister vessel Glen Sannox before it – being hugely behind schedule and multiple times over budget.<br/><br/>There was also nothing about the shock sacking of Ferguson Marine chief executive David Tydeman two weeks ago over “performance” issues, which senior industry officials told me was “unbelievable”. One said: “That guy is the best you have seen by a country mile.”<br/><br/>Glen Sannox left the yard for the last time last week for further sea trials, with the remaining work, including pipework for its liquefied natural gas fuel system, being completed at a dock in Greenock prior to its scheduled completion in May or June, with an update on this due next week.<br/><br/>If there are no further delays, the ferry is expected to start carrying passengers on the main Arran route to Brodick around August following CalMac’s own trials.<br/><br/>Glen Rosa is due to be finished in September next year. But as the crowd of hundreds – families of workers, locals and curious others – watched it slide away into the Clyde, more than just a landmark for drivers on the adjacent A8 has disappeared. The gap now spells “what next?”<br/><br/>Ferguson Marine’s interim chief executive John Petticrew, albeit a born and bred Inverclyde shipbuilder, and yard board member, is very much a caretaker manager, who has effectively been parachuted in for six months from Canada, where he now lives, to “put my best efforts into getting the vessels out of here as quickly as possible”.<br/><br/>Will he do things differently from his predecessor? “It’s a matter

Launch of Glen Rosa at Ferguson Marine

⏲ 6:7 👁 12M

dj smooth

Mikey Spice - I Am I Said - May 2017 (Reggae)

⏲ 4 minutes 6 seconds 👁 11.5M

wise8up

Lucky Dube - Remember Me

⏲ 4 minutes 28 seconds 👁 14.4M

Everton have been penalised for a second time this season by the Premier League after being found guilty of breaching profit and sustainability rules once again.

Everton hit with second points deduction

⏲ 1:0 👁 8.6M

Moviebox Record Label

YO YO HONEY SINGH - DOPE SHOPE (OFFICIAL VIDEO) - INTERNATIONAL VILLAGER

⏲ 3 minutes 15 seconds 👁 7.9M

7clouds

ZAYN & Sia - Dusk Till Dawn (Lyrics)

⏲ 3 minutes 56 seconds 👁 99M

Network Rail is set to begin a 60-million-pound drainage improvement scheme on the rail network across Yorkshire and the North East this month. Over the past year alone, there have been 35 landslips in the north of England, causing major disruption to passengers. This new project aims to increase safety and to minimise disruptions caused by heavy rain across the region.<br/><br/>The North East and Yorkshire route is particularly susceptible to these weather-related disruptions, with rainwater from neighbouring land often overflowing onto railway lines, leading to flooding and major delays.<br/><br/>As part of the new project, 40 new dedicated roles are being created to manage and maintain the new systems being put in place.<br/>Investment will also be made into new and existing technology such as remote condition monitoring circuits and CCTV cameras. Over the next five years, Network Rail plans to invest a total of 2.1-billion-pounds in upgrading the region’s railway lines. Network Rail is set to begin a 60-million-pound drainage improvement scheme on the rail network across Yorkshire and the North East this month. Over the past year alone, there have been 35 landslips in the north of England, causing major disruption to passengers. This new project aims to increase safety and to minimise disruptions caused by heavy rain across the region.<br/><br/>The North East and Yorkshire route is particularly susceptible to these weather-related disruptions, with rainwater from neighbouring land often overflowing onto railway lines, leading to flooding and major delays.<br/><br/>As part of the new project, 40 new dedicated roles are being created to manage and maintain the new systems being put in place.<br/>Investment will also be made into new and existing technology such as remote condition monitoring circuits and CCTV cameras. Over the next five years, Network Rail plans to invest a total of 2.1-billion-pounds in upgrading the region’s railway lines.

Major improvement scheme announced for Northern Rail networks

⏲ 1:0 👁 19.3M

Rock Collection

Michael Bolton Greatest Hits - Best Songs Of Michael Bolton Nonstop Collection ( Full Album)

⏲ 1 hour 25 minutes 49 seconds 👁 933.6K

KoRn

Korn - Got The Life (Official HD Video)

⏲ 4 minutes 8 seconds 👁 52.2M

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