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_the-secrets-of-great-motorcycle-tires.jpg "What makes great sport and racing motorcycle tires? Technical Editor Kevin Cameron and Editor-in-Chief Mark Hoyer dive into the mysterious world of grip, durability, feel, carbon black, silica, and more. Get your carcass in here and have a listen to the latest Cycle World Podcast.<br/><br/>Listen on Spotify: https://open.spotify.com/show/6CLI74xvMBFLDOC1tQaCOQ<br/>Read more from Cycle World: https://www.cycleworld.com/<br/>Buy Cycle World Merch: https://teespring.com/stores/cycleworld")
⏲ 49:19 👁 30.9M
_iconic-forth-bridge-video-that-puts-you-in-the-driver39s-seat.jpg "You may have travelled across the famous bridge before - but you’ve probably not seen it like this<br/><br/>Rail operator ScotRail has shared a unique video of a high-speed train travelling on the Forth Bridge - giving the viewer an idea of what it’s like to be in the driver’s seat.<br/><br/>Filmed in December 2021, the footage was captured when the train was making its way to the scenic village of Boat of Garten in the Highlands as part of ScotRail’s Santa Express attractions. <br/><br/>Video courtesy of ScotRail.")
⏲ 2:12 👁 46.9M
_sugar-series-with-colin-farrell-i-don39t-like-hurting-people.jpg "Sugar - Clip - Series with Colin Farrell - I Don't Like Hurting People - Promo Trailer HD - Not your average post-fight reflections. Sugar is now streaming.<br/><br/>“Sugar” is a contemporary, unique take on one of the most popular and significant genres in literary, motion picture and television history: the private detective story. Academy Award nominee Colin Farrell stars as John Sugar, an American private investigator on the heels of the mysterious disappearance of Olivia Siegel, the beloved granddaughter of legendary Hollywood producer Jonathan Siegel. As Sugar tries to determine what happened to Olivia, he will also unearth Siegel family secrets; some very recent, others long-buried.<br/><br/>The series also stars Kirby (“The Sandman”), Amy Ryan (“The Wire”), Dennis Boutsikaris, Nate Corddry (“Mindhunter”), Alex Hernandez (“Invasion”), and James Cromwell (“Succession”), with guest stars Anna Gunn (“Breaking Bad”) and Sydney Chandler (“Don't Worry Darling”).<br/><br/>“Sugar” is created by Mark Protosevich who also executive produces. Audrey Chon and Simon Kinberg executive produce for Genre Films, marking their second series with Apple TV+ under Kinberg’s overall deal following “Invasion.” Colin Farrell, Sam Catlin, Scott Greenberg and Chip Vucelich also serve as executive producers. The series was directed by Fernando Meirelles (“City of God,” “Two Popes”), who also executive produces, and Adam Arkin (“The Offer”), who also co-executive produces.")
⏲ 1:26 👁 8.4M
![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn5.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.jpg "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
⏲ 1:31 👁 8.3M
_eu-and-ukraine-explore-special-tribunal-for-putin-and-war-officials.jpg "Vladimir Putin and other senior Russian political and military officials could have a special tribunal set up by the EU and Ukraine.")
⏲ 1:0 👁 136.2M
_organic-gardening-made-easy-tips-amp-tricks-for-successful-farming.jpg "It's so satisfying to grow and harvest your own fruits and veggies. We have all the hacks you need for easy and abundant plant growing at home.TIMESTAMPS:08:44 - Melon Cutting Hacks 25:49 - Easy Seeding 49:39 - How to easily propagate plants")
⏲ 1:0:2 👁 69.6M
_knongsrok.jpg "Knongsrok (ក្នុងស្រុក | The local place) is a media travel app and website to explore local places in Cambodia. But wait! Not just local! Worldwide is the best for you if you love travel overseas. For more information you may also go to visit our site (https://www.knongsrok.com) for trip articles.<br/>If you have any feedback or question please don’t feel hesitate to send us message or email derknongsrok@gmail.com<br/><br/>Have a good time on your trip to anywhere. With love @knongsrokteam.")
⏲ 0:22 👁 23.1M
_world-netball-bans-transgender-women-from-international-competitions.jpg "World Netball has banned transgender women from competing in women's international competitions, restricting it to players \")
⏲ 1:0 👁 7M
_hundreds-left-without-power-as-storms-hit-wales.jpg "Wind and flood alerts have been in place across the country, with coastal areas particularly affected.")
⏲ 1:0 👁 10.6M
_launch-of-glen-rosa-at-ferguson-marine.jpg "Launch of Glen Rosa at Ferguson Marine<br/><br/>Glen Rosa launch: What future for Ferguson Marine as hugely-delayed ferry leaves slipway?<br/><br/>It had taken shape at Ferguson Marine over more than eight years, but then, in a matter of seconds on Tuesday, was gone – leaving behind questions about the shipyard’s future (and recent turbulent past) as big as the huge slipway it had just vacated.<br/><br/>Glen Rosa’s belated launch could turn out to be the turning point for the embattled Port Glasgow yard. But we don’t know yet whether it’s towards the brighter future wellbeing economy Mairi McAllan talked up as the ship was sent on its way, or whether the yard’s hopes have effectively sailed away with the vessel.<br/><br/>Ms McAllan, surrounded by female apprentices as she spoke, pointed to them being the future of Scottish shipbuilding, which she said meant it was “in safe hands”.<br/><br/>The Cabinet secretary said later that her officials had just taken receipt of a bid for new investment from the yard to make it more competitive – which could be vital if Ferguson Marine is to secure a crucial contract to build seven smaller CalMac ferries similar to those it successfully completed in the not-so-distant past.<br/><br/>I also understand it will have to bid for the work rather than receive a direct award, to comply with international competition rules. However, Ms McAllan made no reference to Glen Rosa – and sister vessel Glen Sannox before it – being hugely behind schedule and multiple times over budget.<br/><br/>There was also nothing about the shock sacking of Ferguson Marine chief executive David Tydeman two weeks ago over “performance” issues, which senior industry officials told me was “unbelievable”. One said: “That guy is the best you have seen by a country mile.”<br/><br/>Glen Sannox left the yard for the last time last week for further sea trials, with the remaining work, including pipework for its liquefied natural gas fuel system, being completed at a dock in Greenock prior to its scheduled completion in May or June, with an update on this due next week.<br/><br/>If there are no further delays, the ferry is expected to start carrying passengers on the main Arran route to Brodick around August following CalMac’s own trials.<br/><br/>Glen Rosa is due to be finished in September next year. But as the crowd of hundreds – families of workers, locals and curious others – watched it slide away into the Clyde, more than just a landmark for drivers on the adjacent A8 has disappeared. The gap now spells “what next?”<br/><br/>Ferguson Marine’s interim chief executive John Petticrew, albeit a born and bred Inverclyde shipbuilder, and yard board member, is very much a caretaker manager, who has effectively been parachuted in for six months from Canada, where he now lives, to “put my best efforts into getting the vessels out of here as quickly as possible”.<br/><br/>Will he do things differently from his predecessor? “It’s a matter")
⏲ 6:7 👁 6.8M
_39reacher39s39-alan-ritchson-promises-the-season-3-book-will-39make-people-very-happy39-but-adds-a-caveat-that-has-me-co.jpg "Reacher on Amazon Prime is based off the books by Lee Child, with Season 2 adapting the thrilling novel Bad Luck and Trouble. It follows Reacher and Neagley (Maria Sten) as they investigate the murders of two members of their elite special forces unit. But in the run up to Reacher returning to the streaming waves, Ritchson surprised fans with the big news: Season 3 already is in the works. <br/><br/>Alan Ritchson has been active on his social media accounts, sharing images from the set of Reacher Season 3. That is both a vote of confidence for this upcoming season, and a thrill for fans because we won’t have to wait as long to see new episodes once this one has wrapped in January. I got the chance to speak with Ritchson ahead of Reacher Season 2, and as our conversation closed, I asked him which Lee Child book they were going to do for Season 3.")
⏲ 0:47 👁 27.8M
_ridley-scott-describes-his-original-39gladiator-239-opening-scene-with-russell-crowe-and-now-i-need-to-see-this.jpg "Sir Ridley Scott has enjoyed a long and illustrious career, one that extends all the way back to \")
⏲ 1:7 👁 10.7M
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_the-secrets-of-great-motorcycle-tires.webp "What makes great sport and racing motorcycle tires? Technical Editor Kevin Cameron and Editor-in-Chief Mark Hoyer dive into the mysterious world of grip, durability, feel, carbon black, silica, and more. Get your carcass in here and have a listen to the latest Cycle World Podcast.<br/><br/>Listen on Spotify: https://open.spotify.com/show/6CLI74xvMBFLDOC1tQaCOQ<br/>Read more from Cycle World: https://www.cycleworld.com/<br/>Buy Cycle World Merch: https://teespring.com/stores/cycleworld")
_iconic-forth-bridge-video-that-puts-you-in-the-driver39s-seat.webp "You may have travelled across the famous bridge before - but you’ve probably not seen it like this<br/><br/>Rail operator ScotRail has shared a unique video of a high-speed train travelling on the Forth Bridge - giving the viewer an idea of what it’s like to be in the driver’s seat.<br/><br/>Filmed in December 2021, the footage was captured when the train was making its way to the scenic village of Boat of Garten in the Highlands as part of ScotRail’s Santa Express attractions. <br/><br/>Video courtesy of ScotRail.")
_sugar-series-with-colin-farrell-i-don39t-like-hurting-people.webp "Sugar - Clip - Series with Colin Farrell - I Don't Like Hurting People - Promo Trailer HD - Not your average post-fight reflections. Sugar is now streaming.<br/><br/>“Sugar” is a contemporary, unique take on one of the most popular and significant genres in literary, motion picture and television history: the private detective story. Academy Award nominee Colin Farrell stars as John Sugar, an American private investigator on the heels of the mysterious disappearance of Olivia Siegel, the beloved granddaughter of legendary Hollywood producer Jonathan Siegel. As Sugar tries to determine what happened to Olivia, he will also unearth Siegel family secrets; some very recent, others long-buried.<br/><br/>The series also stars Kirby (“The Sandman”), Amy Ryan (“The Wire”), Dennis Boutsikaris, Nate Corddry (“Mindhunter”), Alex Hernandez (“Invasion”), and James Cromwell (“Succession”), with guest stars Anna Gunn (“Breaking Bad”) and Sydney Chandler (“Don't Worry Darling”).<br/><br/>“Sugar” is created by Mark Protosevich who also executive produces. Audrey Chon and Simon Kinberg executive produce for Genre Films, marking their second series with Apple TV+ under Kinberg’s overall deal following “Invasion.” Colin Farrell, Sam Catlin, Scott Greenberg and Chip Vucelich also serve as executive producers. The series was directed by Fernando Meirelles (“City of God,” “Two Popes”), who also executive produces, and Adam Arkin (“The Offer”), who also co-executive produces.")
![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn5.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.webp "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
_eu-and-ukraine-explore-special-tribunal-for-putin-and-war-officials.webp "Vladimir Putin and other senior Russian political and military officials could have a special tribunal set up by the EU and Ukraine.")
_organic-gardening-made-easy-tips-amp-tricks-for-successful-farming.webp "It's so satisfying to grow and harvest your own fruits and veggies. We have all the hacks you need for easy and abundant plant growing at home.TIMESTAMPS:08:44 - Melon Cutting Hacks 25:49 - Easy Seeding 49:39 - How to easily propagate plants")
_knongsrok.webp "Knongsrok (ក្នុងស្រុក | The local place) is a media travel app and website to explore local places in Cambodia. But wait! Not just local! Worldwide is the best for you if you love travel overseas. For more information you may also go to visit our site (https://www.knongsrok.com) for trip articles.<br/>If you have any feedback or question please don’t feel hesitate to send us message or email derknongsrok@gmail.com<br/><br/>Have a good time on your trip to anywhere. With love @knongsrokteam.")
_world-netball-bans-transgender-women-from-international-competitions.webp "World Netball has banned transgender women from competing in women's international competitions, restricting it to players \")
_hundreds-left-without-power-as-storms-hit-wales.webp "Wind and flood alerts have been in place across the country, with coastal areas particularly affected.")
_launch-of-glen-rosa-at-ferguson-marine.webp "Launch of Glen Rosa at Ferguson Marine<br/><br/>Glen Rosa launch: What future for Ferguson Marine as hugely-delayed ferry leaves slipway?<br/><br/>It had taken shape at Ferguson Marine over more than eight years, but then, in a matter of seconds on Tuesday, was gone – leaving behind questions about the shipyard’s future (and recent turbulent past) as big as the huge slipway it had just vacated.<br/><br/>Glen Rosa’s belated launch could turn out to be the turning point for the embattled Port Glasgow yard. But we don’t know yet whether it’s towards the brighter future wellbeing economy Mairi McAllan talked up as the ship was sent on its way, or whether the yard’s hopes have effectively sailed away with the vessel.<br/><br/>Ms McAllan, surrounded by female apprentices as she spoke, pointed to them being the future of Scottish shipbuilding, which she said meant it was “in safe hands”.<br/><br/>The Cabinet secretary said later that her officials had just taken receipt of a bid for new investment from the yard to make it more competitive – which could be vital if Ferguson Marine is to secure a crucial contract to build seven smaller CalMac ferries similar to those it successfully completed in the not-so-distant past.<br/><br/>I also understand it will have to bid for the work rather than receive a direct award, to comply with international competition rules. However, Ms McAllan made no reference to Glen Rosa – and sister vessel Glen Sannox before it – being hugely behind schedule and multiple times over budget.<br/><br/>There was also nothing about the shock sacking of Ferguson Marine chief executive David Tydeman two weeks ago over “performance” issues, which senior industry officials told me was “unbelievable”. One said: “That guy is the best you have seen by a country mile.”<br/><br/>Glen Sannox left the yard for the last time last week for further sea trials, with the remaining work, including pipework for its liquefied natural gas fuel system, being completed at a dock in Greenock prior to its scheduled completion in May or June, with an update on this due next week.<br/><br/>If there are no further delays, the ferry is expected to start carrying passengers on the main Arran route to Brodick around August following CalMac’s own trials.<br/><br/>Glen Rosa is due to be finished in September next year. But as the crowd of hundreds – families of workers, locals and curious others – watched it slide away into the Clyde, more than just a landmark for drivers on the adjacent A8 has disappeared. The gap now spells “what next?”<br/><br/>Ferguson Marine’s interim chief executive John Petticrew, albeit a born and bred Inverclyde shipbuilder, and yard board member, is very much a caretaker manager, who has effectively been parachuted in for six months from Canada, where he now lives, to “put my best efforts into getting the vessels out of here as quickly as possible”.<br/><br/>Will he do things differently from his predecessor? “It’s a matter")
_39reacher39s39-alan-ritchson-promises-the-season-3-book-will-39make-people-very-happy39-but-adds-a-caveat-that-has-me-co.webp "Reacher on Amazon Prime is based off the books by Lee Child, with Season 2 adapting the thrilling novel Bad Luck and Trouble. It follows Reacher and Neagley (Maria Sten) as they investigate the murders of two members of their elite special forces unit. But in the run up to Reacher returning to the streaming waves, Ritchson surprised fans with the big news: Season 3 already is in the works. <br/><br/>Alan Ritchson has been active on his social media accounts, sharing images from the set of Reacher Season 3. That is both a vote of confidence for this upcoming season, and a thrill for fans because we won’t have to wait as long to see new episodes once this one has wrapped in January. I got the chance to speak with Ritchson ahead of Reacher Season 2, and as our conversation closed, I asked him which Lee Child book they were going to do for Season 3.")
_ridley-scott-describes-his-original-39gladiator-239-opening-scene-with-russell-crowe-and-now-i-need-to-see-this.webp "Sir Ridley Scott has enjoyed a long and illustrious career, one that extends all the way back to \")
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