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The application of multiple biophysical techniques to validate initial HTS hits has become an important part of lead discovery. To decipher the mode of action of a new SOS1 inhibitor class, biophysics coupled with the intensive use of structural biology was instrumental.nnIn this case study, we targeted RAS via SOS1, its guanine nucleotide exchange factor. A combination of HTS and fragment screening resulted in the discovery of the first nanomolar SOS1 inhibitors which disrupt the interaction be

[NUVISAN Talk] Targeting RAS via SOS1

⏲ 31 min 27 sec ✓ 20-Oct-2022

Investox

Products of ITC India | Top Products of ITC in India | How many products ITC India is having |

⏲ 4 minutes 27 seconds 👁 29.2K

pranjal kamra

How to analyze FMCG stocks like ITC, HUL | How to pick FMCG stocks | Stock market classes episode 9

⏲ 17 minutes 45 seconds 👁 160.2K

At the 2024 Forbes 30/50 Summit, movie star, Alia Bhatt, sits with Forbes senior editor, Maggie McGrath, for an interview covering the actor's career, entrepreneurial endeavors and her upcoming film, 'Jigra.'<br/><br/>Subscribe to FORBES: https://www.youtube.com/user/Forbes?sub_confirmation=1<br/><br/>Fuel your success with Forbes. Gain unlimited access to premium journalism, including breaking news, groundbreaking in-depth reported stories, daily digests and more. Plus, members get a front-row seat at members-only events with leading thinkers and doers, access to premium video that can help you get ahead, an ad-light experience, early access to select products including NFT drops and more:<br/><br/>https://account.forbes.com/membership/?utm_source=youtube&utm_medium=display&utm_campaign=growth_non-sub_paid_subscribe_ytdescript<br/><br/>Stay Connected<br/>Forbes newsletters: https://newsletters.editorial.forbes.com<br/>Forbes on Facebook: http://fb.com/forbes<br/>Forbes Video on Twitter: http://www.twitter.com/forbes<br/>Forbes Video on Instagram: http://instagram.com/forbes<br/>More From Forbes:http://forbes.com<br/><br/>Forbes covers the intersection of entrepreneurship, wealth, technology, business and lifestyle with a focus on people and success.

Bollywood Star Alia Bhatt Just Wants To Be 'A Kind Human Being'

⏲ 19:55 👁 33M

ITCCorpCom

ITC Brands that delight India!

⏲ 2 minutes 49 seconds 👁 8K

Sarah 's Videos

Top 10 ITCProducts.

⏲ 1 minute 39 seconds 👁 27.1K

It’s a rare feat to become a billionaire, especially at a young age. The average billionaire is 66, and the oldest person in the ranks is 102. Still, a select few have gotten super-rich super young.<br/><br/>For the first time since 2009, every billionaire under 30 inherited his or her fortune—the result of some self-made entrepreneurs aging into their 30s, and a sign that the “great wealth transfer” has begun.<br/><br/>These inheritances illustrate the beginning of a long-anticipated generational wealth transfer among aging populations around the world. In the United States, Baby Boomers and their elders (those born in 1964 or earlier) hold $95.9 trillion of a total $147.1 trillion of household wealth, per the Federal Reserve. Trillions are expected to change hands every year as the affluent elderly pass away and leave their fortunes to descendants.<br/><br/>Read the full story on Forbes: https://www.forbes.com/sites/monicahunter-hart/2024/03/31/worlds-youngest-billionaires-2024-john-collison-ben-francis-evan-spiegel/?sh=3a7d65a61352<br/><br/>Subscribe to FORBES: https://www.youtube.com/user/Forbes?s... <br/><br/>Fuel your success with Forbes. Gain unlimited access to premium journalism, including breaking news, groundbreaking in-depth reported stories, daily digests and more. Plus, members get a front-row seat at members-only events with leading thinkers and doers, access to premium video that can help you get ahead, an ad-light experience, early access to select products including NFT drops and more: <br/><br/>https://account.forbes.com/membership... <br/><br/>Stay Connected <br/>Forbes newsletters: https://newsletters.editorial.forbes.com <br/>Forbes on Facebook: http://fb.com/forbes <br/>Forbes Video on Twitter: / forbes <br/>Forbes Video on Instagram: / forbes <br/>More From Forbes: http://forbes.com <br/><br/>Forbes covers the intersection of entrepreneurship, wealth, technology, business and lifestyle with a focus on people and success.

The Top 5 Wealthiest Young Billionaires In 2024

⏲ 3:12 👁 11.4M

Placify

ITC Limited VS HUL Limited Company Comparison in Hindi |ITC VS HUL Comparison 2024

⏲ 6 minutes 11 seconds 👁 61.6K

ITCCorpCom

ITC Foods Manufacturing & Logistics Facility, Kapurthala, Punjab

⏲ 27 seconds 👁 16.3K

What a year it’s been for the planet’s billionaires, whose fortunes continue to swell as global stock markets shrug off war, political unrest and lingering inflation. There are now more billionaires than ever: 2,781 in all, 141 more than last year and 26 more than the record set in 2021. They’re richer than ever, worth $14.2 trillion in aggregate, up by $2 trillion from 2023 and $1.1 trillion above the previous record, also set in 2021. Two-thirds of the list’s members are worth more than a year ago; only one fourth are poorer. Much of the gains come from the top 20, who added a combined $700 billion in wealth since 2023, and from the U.S., which now boasts a record 813 billionaires worth a combined $5.7 trillion. China remains second, with 473 (including Hong Kong) worth $1.7 trillion, despite weak consumer spending and a real estate bust that helped wipe out $200 billion in wealth and knocked 89 billionaires from the ranks. India, which has 200 billionaires (also a record), ranks third.To calculate net worths, we used stock prices and exchange rates from March 8, 2024. See below for the full list of the world’s billionaires and our methodology. For daily updated net worths of all 2,781 billionaires, check out our real-time billionaires rankings.<br/><br/>Read the full story on Forbes: https://www.forbes.com/sites/chasewithorn/2024/04/02/the-100-billion-club-these-14-people-have-12-figure-fortunes/<br/><br/>Subscribe to FORBES: https://www.youtube.com/user/Forbes?sub_confirmation=1<br/><br/>Fuel your success with Forbes. Gain unlimited access to premium journalism, including breaking news, groundbreaking in-depth reported stories, daily digests and more. Plus, members get a front-row seat at members-only events with leading thinkers and doers, access to premium video that can help you get ahead, an ad-light experience, early access to select products including NFT drops and more:<br/><br/>https://account.forbes.com/membership/?utm_source=youtube&utm_medium=display&utm_campaign=growth_non-sub_paid_subscribe_ytdescript<br/><br/>Stay Connected<br/>Forbes newsletters: https://newsletters.editorial.forbes.com<br/>Forbes on Facebook: http://fb.com/forbes<br/>Forbes Video on Twitter: http://www.twitter.com/forbes<br/>Forbes Video on Instagram: http://instagram.com/forbes<br/>More From Forbes:http://forbes.com<br/><br/>Forbes covers the intersection of entrepreneurship, wealth, technology, business and lifestyle with a focus on people and success.

The 5 Richest Billionaires In The World 2024

⏲ 4:36 👁 10.8M

GE Aerospace, formerly GE Aviation, has spun off as a separate company based in Evendale, Ohio. The spinoff is part of General Electric's breakup of its industrial conglomerate into multiple standalone businesses. GE Aerospace expects over $6 billion in annual profits, growing to as much as $10 billion by 2028. The company is investing over $100 million in its Evendale plant, employing around 9,000 local workers. The UAW local president welcomed the opportunities for expanded employment and manufacturing at the Evendale site.

GE Aerospace Spins Off as Standalone Company, Expects Billions in Profits and Job Growth

⏲ 0:48 👁 8.4M

When Larry Culp stepped into the CEO role at General Electric in 2018, he was the first outsider to lead the iconic company. Founded by Thomas Edison in 1892, GE had morphed over more than a century into a sprawling conglomerate that was struggling under $135 billion in debt.<br/><br/>One of Culp’s predecessors had made a costly acquisition bet, investors had fled, and the company’s market cap had shrunk to $70 billion, down more than half a trillion dollars from August 2000, when it was the most valuable company in the world. Culp turned GE’s board down twice before accepting the CEO job, but ultimately extracted a multimillion-share incentive package linked to GE’s share price. At the time, CNBC’s Jim Cramer said it was “the best performance-oriented contract I’ve ever seen.”<br/><br/>Spoiler alert: It paid off.<br/><br/>Read the full story on Forbes: https://www.forbes.com/sites/sarahwhitmire/2024/03/31/general-electric-ceo-larry-culp-to-join-small-club-of-billionaire-executives/?sh=7902b57d449b<br/><br/>Subscribe to FORBES: https://www.youtube.com/user/Forbes?sub_confirmation=1<br/><br/>Fuel your success with Forbes. Gain unlimited access to premium journalism, including breaking news, groundbreaking in-depth reported stories, daily digests and more. Plus, members get a front-row seat at members-only events with leading thinkers and doers, access to premium video that can help you get ahead, an ad-light experience, early access to select products including NFT drops and more:<br/><br/>https://account.forbes.com/membership/?utm_source=youtube&utm_medium=display&utm_campaign=growth_non-sub_paid_subscribe_ytdescript<br/><br/>Stay Connected<br/>Forbes newsletters: https://newsletters.editorial.forbes.com<br/>Forbes on Facebook: http://fb.com/forbes<br/>Forbes Video on Twitter: http://www.twitter.com/forbes<br/>Forbes Video on Instagram: http://instagram.com/forbes<br/>More From Forbes:http://forbes.com<br/><br/>Forbes covers the intersection of entrepreneurship, wealth, technology, business and lifestyle with a focus on people and success.

CEO Larry Culp's Overhaul Of GE Will Make Him A Billionaire

⏲ 5:18 👁 9.3M

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