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A young girl has died and two women injured after a car ploughed into them on a residential street in Birmingham. <br/><br/>Emergency services rushed to Upper Highgate Street, in the Highgate area of the city, after four pedestrians were mown down at 9.45pm yesterday (Sun).<br/><br/>Paramedics battled to save the child but she was confirmed dead at the scene while two women were taken to hospital with serious injuries.<br/><br/>A second child was also assessed by ambulance crews but did not require any further treatment. <br/><br/>West Midlands Ambulance Service said three ambulances, two paramedic officers, a MERIT trauma doctor and two critical care paramedics were sent to the scene.<br/><br/>A service spokeswoman said: “On arrival, crews found a car and four pedestrians had been involved in a collision.<br/><br/>“A child, female, was in a critical condition and ambulance staff immediately began administering advanced life support.<br/><br/>“Sadly, despite everyone’s best efforts, she could not be saved and was confirmed dead at the scene.<br/><br/>“Two women were treated by medics for serious, but not life-threatening, injuries and were conveyed on blue lights to Queen Elizabeth Hospital in Birmingham for further treatment.<br/><br/>“A fourth patient, a child, was assessed by ambulance crews but was not injured and so was discharged at the scene.”
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Neuroscience Breakthrough , Could Lead to New Treatments for , Spinal Cord Injuries.<br/>'Newsweek' reports that neuroscientists have <br/>discovered that the human spinal cord is capable of <br/>making its own memories independent of the brain.<br/>The discovery, which challenges previous <br/>ideas about neural circuits outside of the brain,<br/>could represent a breakthrough for people <br/>recovering from spinal cord injuries. .<br/>Learning and memory is<br/>often attributed as functions <br/>of the brain exclusively, Aya Takeoka, principal investigator at Japan's <br/>RIKEN Center for Brain Science, via 'Newsweek'.<br/>Although scientists knew for <br/>more than a century that the <br/>spinal cord could learn and adapt <br/>movements in the absence of brain <br/>input, we did not know how <br/>the spinal cord learns and <br/>memorize what is has learned, Aya Takeoka, principal investigator at Japan's <br/>RIKEN Center for Brain Science, via 'Newsweek'.<br/>Gaining insights into the underlying <br/>mechanism is essential if we want <br/>to understand the foundations <br/>of movement automaticity in <br/>healthy people and use this <br/>knowledge to improve recovery <br/>after spinal cord injury, Aya Takeoka, principal investigator at Japan's <br/>RIKEN Center for Brain Science, via 'Newsweek'.<br/>The team of neuroscientists looked to demonstrate <br/>how spinal cord cells can adapt to sensory inputs <br/>without receiving any signals from the brain.<br/>The two groups of nerve cells have <br/>distinct functions; learning cells are <br/>not needed for recalling what the <br/>spinal cord had learned, and memory <br/>cells were not needed for learning, Aya Takeoka, principal investigator at Japan's <br/>RIKEN Center for Brain Science, via 'Newsweek'.<br/>The team hopes their results could help <br/>develop new rehabilitative training methods <br/>for patients with spinal cord damage.<br/>Not only do these results challenge <br/>the prevailing notion that motor learning <br/>and memory are solely confined to brain <br/>circuits, but we showed that we could <br/>manipulate spinal cord motor recall, <br/>which has implications for therapies <br/>designed to improve recovery <br/>after spinal cord damage, Aya Takeoka, principal investigator at Japan's <br/>RIKEN Center for Brain Science, via 'Newsweek'.<br/>The team's findings <br/>were published in the <br/>journal 'Science.'
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May 2021nSponsored by @MetrumRGnPlease join us for a follow-up learning opportunity, building on the ASCPT 2021 Annual Meeting session: Opportunities at the Intersection of Pharmacometrics and Health Economics for Insightful Drug Development Decision Making. This special presentation will provide a detailed review of a prototypical web-based interactive simulation app which allows for the exploration of expected relationships between pharmacometric characteristics of hypothetical new treatments
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A mum-to-be was diagnosed with cancer at five months pregnant - when her extreme morning sickness turned out to be a symptom of the disease. <br/><br/>Caitlin McAlinden, 24, put her cancer symptoms - including a golf ball-sized lump on her neck, nausea and fatigue - down to morning sickness.<br/><br/>But after losing two stone in four months she was referred to a haematology team at Arrowe Park, the Wirral. <br/><br/>They gave her a neck biopsy and diagnosed her with stage one Hodgkin lymphoma in March 2024. <br/><br/>Caitlin is expected to make a full recovery but has to take a steroid injection and a blood-thinning pill every morning. <br/><br/>After her baby boy is born, on May 8, she’ll start a four-week course of chemotherapy. <br/><br/>Caitlin, a primary school teacher, from Wirral, Merseyside, said: “This isn’t the pregnancy I was hoping for - I haven’t felt well this entire time. <br/><br/>“Everything I want to do after my baby is born has to be put on pause due to the chemo. <br/><br/>“My odds are really good - but having my baby will be a good distraction for everything I’m going through.”<br/><br/>Caitlin found out she was pregnant on September 16, 2023 - after feeling nauseous at her birthday dinner the week before. <br/><br/>Her first trimester was “rocky” and she originally believed she had a severe form of morning sickness.<br/><br/>She was vomiting at least once a day and would fall asleep intermittently throughout the day. <br/><br/>But it wasn’t until Christmas Day that she first noticed the pain in her neck and after weighing herself, noticed she’d lost two stone. <br/><br/>She said: “I went back to County Armagh to visit my family for Christmas. <br/><br/>“I remember Christmas Day, falling asleep on the sofa and waking up with a really sore neck. <br/><br/>“I thought I’d just slept funny, but I started massaging my neck.<br/><br/>“That’s when I found a lump, about the size of a pea.”<br/><br/>Caitlin didn’t want to see a GP at first - believing the lump was just another “weird” sign of pregnancy. <br/><br/>But in just a week, her tiredness became worse and the pea-size lump tripled in size.<br/><br/>“I was so, so tired,” she said. <br/><br/>“Walking up the stairs alone would make me need to go for a lie down.<br/><br/>“I felt my neck again one day and the lump had become golf ball-sized.”<br/><br/>Her partner, Connor, 27, a procurement manager, told Caitlin she needed to see a doctor as soon as possible. <br/><br/>She visited her GP on January 2 and was referred for an initial ultrasound on her neck. <br/><br/>They gave her a biopsy on January 16 and the clinician asked Caitlin if she had any family history of Hodgkin lymphoma. <br/><br/>She told them one of her second cousins had gone through it years before and they urgently sent her for more blood tests. <br/><br/>“My doctor’s whole demeanour changed when I said I had a family history of it,” Caitlin said. <br/><br/>“I went for a blood test on the same day.”<br/><br/>Caitlin was diagnosed with stage one Hodgkin lymphoma on March 12, 2024, and instantly started steroid treatment to shrink the mass on her neck.
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