_optimisation-of-nanb-inhibitiors-based-upon-ches-part-2.jpg "Optimisation of NanB Inhibitiors based upon CHES part 2 from nanb Video Screenshot Preview")
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⏲ Duration: 74 sec
✓ Published: 21-Aug-2016
✓ Published: 21-Aug-2016
Description:
This is Part 2 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem). The active site of NanB is covered by a flexible loop. This loop is normally held in position by a well defined water. In the structure with taurine the water can be seen and the loop is rigid, as can be seen from the B-factor putty representation (increased size and red means larger B-f
This is Part 2 of a summary of the crystal structures presented in Synthesis and Structural Characterisation of Selective Non-Carbohydrate-Based Inhibitors of Bacterial Sialidases - (Brear - 2012 - ChemBioChem). The active site of NanB is covered by a flexible loop. This loop is normally held in position by a well defined water. In the structure with taurine the water can be seen and the loop is rigid, as can be seen from the B-factor putty representation (increased size and red means larger B-f
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