_got-blood-how-3d-genomics-detects-structural-variants-in-pediatric-leukemia-patients.jpg "Got Blood? How 3D Genomics Detects Structural Variants in Pediatric Leukemia Patients from fish cancer testing Video Screenshot Preview")
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⏲ Duration: 35 min 18 sec
✓ Published: 27-Oct-2022
✓ Published: 27-Oct-2022
Description:
Translocations and other structural variants (SV) are common in patients with B-cell acute lymphoblastic leukemia (B-ALL). Identification of the specific SV present within a patient sample can inform patient prognosis as well as guide patient treatment, but existing testing is often painful and invasive. Here, we demonstrate how Hi-C sequencing serves as a viable alternative to current clinical tests based on fluorescence in situ hybridization (FISH) assays.
Translocations and other structural variants (SV) are common in patients with B-cell acute lymphoblastic leukemia (B-ALL). Identification of the specific SV present within a patient sample can inform patient prognosis as well as guide patient treatment, but existing testing is often painful and invasive. Here, we demonstrate how Hi-C sequencing serves as a viable alternative to current clinical tests based on fluorescence in situ hybridization (FISH) assays.
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