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![Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'](https://cdn1.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KAxb3EmSwAJgZpx13nJ9-FF9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_newly-discovered-gene-variant-could-help-prevent-or-treat-alzheimer39s-disease.webp "Newly-Discovered Gene Variant , Could Help Prevent or Treat , Alzheimer's Disease.<br/>'Newsweek' reports that scientists have uncovered <br/>a genetic variant that has the potential to reduce <br/>the odds of developing Alzheimer's by as much as 70%.<br/>The discovery could reportedly lead to new methods to <br/>effectively treat or prevent the disease which impacts <br/>approximately 5.8 million people in the United States alone.<br/>Some genetic variants have been found to have an <br/>association with an increased likelihood of developing <br/>the disease, while other variants offer protection. .<br/>A team from Columbia University found that <br/>genes involved with the production of fibronectin <br/>play a crucial role in developing Alzheimer's.<br/>Healthy individuals usually only have fibronectin present <br/>in small amounts along their blood-brain barrier, while <br/>those with Alzheimer's have much higher quantities.<br/>It's a classic case of too much <br/>of a good thing. It made us think <br/>that excess fibronectin could be <br/>preventing the clearance of [abnormal <br/>protein clumps] from the brain, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The team believes that methods aimed at reducing <br/>fibronectin could play a crucial role in developing <br/>new treatments and preventative measures. .<br/>Anything that reduces excess <br/>fibronectin should provide some <br/>protection, and a drug that does <br/>this could be a significant step <br/>forward in the fight against <br/>this debilitating condition, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>Our findings suggest that...<br/>we may be able to develop new <br/>types of therapies that mimic <br/>the gene's protective effect <br/>to prevent or treat the disease, Caghan Kizil, co-leader of the study and professor of <br/>neurological sciences at Columbia University's Vagelos <br/>College of Physicians and Surgeons, via 'Newsweek'.<br/>The Columbia University team's <br/>findings were published in the <br/>journal 'Acta Neuropathologica.'")
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_e-bike-trial-for-tenby-and-other-parts-of-pembrokeshire-launched.webp "Residents and visitors to four Pembrokeshire areas - including the seaside town of Tenby - are being invited to get on their bikes following the introduction of an exciting pay as you go E-bike trial.<br/>Thanks to funding of £150,000 from the Swansea Bay and South West Wales Metro programme, as well as Tenby, the trial will run in Haverfordwest, Fishguard andGoodwick for 12 months.<br/>The trial conducted by Pembrokeshire County Council, which starts this month, will see a fleet of E-bikes provided for members of the public to use for commuting, leisure and local activities.<br/>Users will simply be able to collect and leave E-bikes at a handy series of pick-up and drop-off sites around the towns.<br/>E-bikes are a combination of a conventional bike with a motor that take some of the effort out of pedalling for the rider. They cover greater distances in less time and with less effort than conventional cycles.<br/>The aim is to give residents and visitors an alternative method of travel rather than rely upon cars for short trips under 2km.<br/>This will in turn create a healthier and decarbonised Pembrokeshire and help towards National Decarbonisation Targets.<br/>Zipp Mobility will maintain the bikes throughout the trial period, including ensuring batteries are charged and ready to go.<br/>Cllr Rhys Sinnett, Cabinet Member for Residents’ Services said: “The successful application for the Southwest Wales Metro Funding has allowed investment in this exciting and environmentally friendly transport.<br/>“The towns will be involved in a pilot scheme to encourage residents, commuters, and visitors to utilise the electric bikes via a low-cost scheme.<br/>“We hope that if people need to do a short journey they will consider hopping on one of the conveniently placed E-bikes rather than immediately turning to a car.<br/>“If successful it is hoped that the scheme can be extended to other parts of the county”.<br/>Users will need to be over 18 and will access the E-bikes through the Zipp Mobility app via mobile phones. Download the app and register to get ready to ride. The app also provides details of costs.<br/>The E-bikes must be collected from and returned to a series of bays across each of the towns.<br/><br/>Video: ©PCC")
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